Gum disease tied to cancer, others

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Add one more reason to why you should brush and floss regularly: Gum disease bacteria are now tied to higher odds of oesophageal cancer.

The study tracked the oral health of 122,000 Americans for 10 years. It found that the presence of two types of bacteria linked with gum disease may hike the risk of the cancer.

The study findings were published December 1 in the journal Cancer Research.

The presence of one oral bacterium in particular, called Tannerella forsythia, was tied to a 21 percent increase in the odds of developing esophageal tumors, said a team led by Jiyoung Ahn. She is associate director for population science at NYU Langone Health in New York City, United States (U.S.).

Gum disease has already been linked in numerous studies to a heightened risk of the number one killer, heart disease. But an expert in oesophageal cancer who reviewed the new findings stressed that researchers can’t yet prove a causal link to esophageal tumors.

“What is not clear is whether the presence of these bacteria or the resultant periodontal disease is primarily responsible for the development of cancer,” said Dr. Anthony Starpoli, associate director of esophageal endotherapy at Lenox Hill Hospital in New York City.

Still, Starpoli believes specialists should “consider a proper evaluation of the oral cavity as well as the remainder of the digestive tract in the hope of early diagnosis of esophageal cancer.”

Oesophageal cancer is the eighth most common cancer and the sixth leading cause of cancer death worldwide, the study authors noted. Because it’s often only diagnosed at an advanced stage, five-year survival rates are between 15 to 25 percent.

Ahn said, “Esophageal cancer is a highly fatal cancer, and there is an urgent need for new avenues of prevention, risk stratification, and early detection.”

The news from the study was not all bad: The investigators found that some types of mouth bacteria were associated with a lower risk of esophageal cancer.

Learning more about the bacteria communities living naturally in the mouth “may potentially lead to strategies to prevent esophageal cancer, or at least to identify it at earlier stages,” Ahn noted in a news release from the American Association for Cancer Research.

One other expert agreed. “The study suggests that there are some oral bacteria that may contribute to the development of this highly deadly cancer but also, and very importantly, suggests that some bacteria may provide a protective effect,” said Dr. Robert Kelsch. He’s an oral pathologist at Northwell Health in New Hyde Park, N.Y.

“Knowing which bacteria are good and which are bad could lead to preventive treatments or serve as predictors of risk of development of this cancer,” Kelsch said.

Ahn added that good oral health — including regular tooth brushing and dental visits — may help protect against gum disease and health conditions associated with it.

Also, researchers have evaluated a new dental material tethered with an antimicrobial compound that can not only kill bacteria but can also resist biofilm growth. In addition, unlike some drug-infused materials, it is effective with minimal toxicity to the surrounding tissue, as it contains a low dose of the antimicrobial agent that kills only the bacteria that come in contact with it.

Dentists rely on composite materials to perform restorative procedures, such as filling cavities. Yet these materials, like tooth enamel, can be vulnerable to the growth of plaque, the sticky biofilm that leads to tooth decay.

credit: TheGuardian

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